Phospholipase C, Gamma-2

Alternative Names

PLCG2
Phospholipase C, Phosphatidylinositol-Specific

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Length

183,395 bases

No. of Exons

No. of isoforms

Protein Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Molecular Mass

147870 Da

Amino Acid Count

1265

Genomic Location

chr16:81,779,290-81,962,684

Gene Map Locus

16q23.3

Description

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. [From RefSeq]

Epidemiology in the Arab World

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Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_002661.5:c.82A>T	Lebanon	NC_000016.10:g.81786071A>T	Benign	Uncertain Significance		NG_032019.2:g.51975A>T; NM_002661.5:c.82A>T; NP_002652.2:p.Met28Leu	61749044	440153

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External Links

https://medlineplus.gov/genetics/gene/plcg2/ https://www.genecards.org/cgi-bin/carddisp.pl?gene=plcg2

Contributors

Sayeeda Hana: 07.02.2021

Edit History

Sayeeda Hana: 07.02.2021