Interleukin 1 Receptor, Type II

Alternative Names

  • IL1R2
  • Interleukin 1 Receptor, Beta, Type II
  • IL1RB
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OMIM Number

147811

NCBI Gene ID

7850

Uniprot ID

P27930

Length

36,740 bases

No. of Exons

15

No. of isoforms

2

Protein Name

Interleukin-1 receptor type 2

Molecular Mass

45421 Da

Amino Acid Count

398

Genomic Location

chr2:101,991,804-102,028,543

Gene Map Locus
2q11.2

Description

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_004633.4:c.932T>CLebanonNC_000002.12:g.102026155T>CUncertain SignificanceFamilial Mediterranean FeverNM_004633.4:c.932T>C; NP_004624.1:p.Ile311Thr144482163
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