Fibrinogen, B Beta Polypeptide

Alternative Names

  • FGB
  • Fibrinogen--Beta Polypeptide Chain

Associated Diseases

Stroke, Ischemic
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OMIM Number

134830

NCBI Gene ID

2244

Uniprot ID

P02675

Length

9,828 bases

No. of Exons

8

No. of isoforms

1

Protein Name

Fibrinogen beta chain

Molecular Mass

55928 Da

Amino Acid Count

491

Genomic Location

chr4:154,562,979-154,572,806

Gene Map Locus
4q31.3

Description

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinical SignificanceCondition(s)HGVS ExpressionsdbSNPClinvar
NM_005141.5:c.-455G>ALebanonNC_000004.12:g.154562556G>AUncertain SignificanceStroke, IschemicNG_008833.1:g.4577G>A; NM_005141.5:c.-455G>A180079016388
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