Group-Specific Component

Alternative Names

  • GC
  • Vitamin D-Binding Protein
  • DBP
  • VDBP
  • Vitamin D-Binding Alpha-Globulin
  • VDBG
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OMIM Number

139200

NCBI Gene ID

2638

Uniprot ID

P02774

Length

63,828 bases

No. of Exons

15

No. of isoforms

3

Protein Name

Vitamin D-binding protein

Molecular Mass

52918 Da

Amino Acid Count

474

Genomic Location

chr4:71,741,692-71,805,519

Gene Map Locus
4q13.3

Description

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinical SignificanceCondition(s)HGVS ExpressionsdbSNPClinvar
NM_000583.4:c.1296T>GLebanonNC_000004.12:g.71752617A>CBenignNG_012837.3:g.57904T>G; NM_000583.4:c.1296T>G; NP_000574.2:p.Asp432Glu704115987
NM_000583.4:c.1307C>ALebanonNC_000004.12:g.71752606G>TBenignNG_012837.3:g.57915C>A; NM_000583.4:c.1307C>A; NP_000574.2:p.Thr436Lys458815986
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