Prostate Cancer

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WHO-ICD-10 version:2010

Neoplasms

Malignant neoplasms

OMIM Number

176807

Mode of Inheritance

Autosomal dominant, Somatic mutations

Gene Map Locus

1q25, 1q42.2-q43,3p26,7p22.3,8p22,10p15.2, 10q23.31, 10q25.2,11p11.2,13q13.1,16q22.1, 16q22.2-q22.3 ,17p11,19q,20q13,22q12.1,Xq12

Description

Prostate cancer is a general term used to describe a common malignant tumor, almost of glandular origin (adenocarcinoma), in the prostate gland. The prostate gland is a specific organ in males containing cells that make some of the seminal fluid. This gland locates below the bladder, in front of the rectum and it develops continuously since the fetal life under the stimulation of male hormones (androgen). As a man becomes older, the part of the prostate around the urethra often keeps on growing causing benign prostatic hyperplasia (BPH) which can result in problems with urinating. However, BPH may develop later leading to malignant neoplasm (prostate cancer).

Epidemiology in the Arab World

View Map
Subject IDCountrySexFamily HistoryParental ConsanguinityHPO TermsVariantZygosityMode of InheritanceReferenceRemarks
176807.G.1.1LebanonMale Prostate cancer... NM_000376.3:c.1056T>C, NM_000376.2:c.1024+283G>A, NM_000376.3:c.1025-49G>T, NM_000102.4:c.-34T>CEl Ezzi et al. 2017 69 patients with con...
176807.G.2.1LebanonMale Prostate cancer... NM_000789.4:c.2306-105_2306-104insTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCATACAGTCACTTTTEl Ezzi et al. 2020 69 Lebanese patients...

Other Reports

Egypt

[See also: United Arab Emirates > Ghafoor et al., 2003].

Jordan

Abu Farsakh and Abu Farsakh (2008) evaluated 348 prostate biopsies, performed in a 4-year period. Of these cases, 43% were diagnosed as having adenocarcinoma. The mean age for cancer patients was 68.4 years.

[See also: United Arab Emirates > Ghafoor et al., 2003].

Kuwait

Kehinde et al. (2003) investigated serum PSA levels in 1700 Arab men residing in Kuwait and presenting with prostatitis over a 4-year period between 1998 and 2002. Of the 161 patients with PSA levels elevated over 10ng/ml, only 18 (11%) were found to have prostate cancer, while upto 88% were found to have benign prostatic hyperplasia (BPH), either alone or with prostatitis. The results pointed towards prostatitis and/or BPH being a common cause of high PSA levels among Arab men than prostate cancer.

Narayanaswamy et al. (2011) analyzed the data related to 153 males suspected of having prostate cancer, between January 2003 and January 2008, based on elevation of prostate-specific antigen (PSA) of more than 4 ng/ml. A diagnosis of prostate cancer was histologically confirmed in 42 (27%) patients. In those aged <55, 56-65, 66-75 and >76 years, the detection rates were 17, 18, 33 and 41%, respectively. Narayanaswamy et al. (2011) indicated that prostate cancer rates reveal regional differences and that the rate they have observed was low. They also added that higher PSA and higher number of diagnostic tools with abnormal findings were associated with a higher incidence of prostate cancer.

Oman

[See: United Arab Emirates > Ghafoor et al., 2003; Kuwait > Kehinde et al., 2006].

Syria

[See: United Arab Emirates > Ghafoor et al., 2003].

United Arab Emirates

Ghafoor et al. (2003) evaluated the magnitude of prostate cancer in the United Arab Emirates (UAE) using a descriptive retrospective study. The study series consisted of 84 prostate cancer patients, diagnosed and treated at Tawam and Al-Ain Hospitals during the period from 1982 to 2000, with the ages ranging from 38 to 81 years. The study revealed that majority of the patients (n = 33, 39.2%) were diagnosed between 51 to 60 years of age. The majority of the patients were UAE nationals (44.0%), followed by patients from neighboring countries i.e. Oman, Yemen, Syria, Jordan and Egypt (40.5%). Ghafoor et al. (2003) calculated the annual incidence of prostate cancer in the male UAE population to be about 4.5/100,000; a very low rate when compared to Western Countries despite the high intake of calories and consumption of animal fat.

Yemen

[See also: United Arab Emirates > Ghafoor et al., 2003].

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